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GH administration causes rapid upregulation of IGF-I mRNA and protein in the liver (Mathews et al ., 1986) and animals with liver-specific IGF-I deletions show only 10–25% of serum IGF-I levels compared with controls (Sjögren et al ., 1999

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4 , 13 , 15 As the spherocytes attempt to move through the narrow, elliptical fenestrations of the endothelial cells lining the splenic sinusoids, they acquire further membrane loss or become trapped and are rapidly removed by the macrophages of the red pulp of the spleen